Divergent Approach to a Family of Tyrosine-Derived Ru−Alkylidene Olefin Metathesis Catalysts


Ellen C. Gleeson, Zhen J. Wang, W. Roy Jackson, and Andrea J. Robinson

Published Journal of Organic Chemistry
Graphical abstract



A simple and generic approach to access a new family of Ru−alkylidene olefin metathesis catalysts with specialized properties is reported. This strategy utilizes a late stage, utilitarian Hoveyda-type ligand derived from tyrosine, which can be accessed via a multigram-scale synthesis. Further functionalization allows the catalyst properties to be tuned, giving access to modified second-generation Hoveyda−Grubbs-type catalysts. This divergent synthetic approach can be used to access solid-supported catalysts and catalysts that function under solvent-free and aqueous conditions.


Ellen C. Gleeson, Zhen J. Wang, W. Roy Jackson, and Andrea J. Robinson, J. Org. Chem., 201580(14), 7205–7211

Pdf Article
Doi https://doi.org/10.1021/acs.joc.5b01091
Subjects Ligands, Precursors, Catalysts, Olefin metathesis, Metathesis
This entry was posted in Metathesis, Publications 2015. Bookmark the permalink.

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