Category Archives: Conotoxins

α-Conotoxin Peptidomimetics: Probing the Minimal Binding Motif for Effective Analgesia

Authors Adam C. Kennedy, Alessia Belgi, Benjamin W. Husselbee, David Spanswick, Ray S. Norton, Andrea J. Robinson Published Toxins Graphical abstract   Abstract Several analgesic α-conotoxins have been isolated from marine cone snails. Structural modification of native peptides has provided … Continue reading

Posted in Conotoxins, Publications 2020 | Leave a comment

Alkyne-Bridged α-Conotoxin Vc1.1 Potently Reverses Mechanical Allodynia in Neuropathic Pain Models

Authors Alessia Belgi, James V. Burnley, Christopher A. MacRaild, Sandeep Chhabra, Khaled A. Elnahriry, Samuel D. Robinson, Simon G. Gooding, Han-Shen Tae, Peter Bartels, Mahsa Sadeghi, Fei-Yue Zhao, Haifeng Wei, David Spanswick, David J. Adams, Ray S. Norton, Andrea. J. … Continue reading

Posted in Conotoxins, Publications 2021 | Leave a comment

Dicarba Analogues of α-Conotoxin RgIA. Structure, Stability and Activity at Potential Pain Targets

Authors Sandeep Chhabra, Alessia Belgi, Peter Bartels, Bianca van Lierop, Samuel D. Robinson, Shiva N. Kompella, Andrew Hung, Brid P. Callaghan, David J. Adams, Andrea J. Robinson and Raymond S. Norton Published Journal of Medicinal Chemistry Graphical abstract   Abstract … Continue reading

Posted in Conotoxins, Metathesis, Publications, Publications 2014 | Leave a comment

Dicarba α‐Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors

Authors Bianca J. van Lierop, Samuel D. Robinson, Shiva N. Kompella, Alessia Belgi, 
Jeffrey R. McArthur, Andrew Hung, Christopher A. MacRaild, David J. Adams, Raymond S. Norton and Andrea J. Robinson Published  ACS Chemical Biology Graphical abstract   Abstract Conotoxins … Continue reading

Posted in Conotoxins, Dicarba peptides, Metathesis, Publications, Publications 2013 | Leave a comment