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Category Archives: Publications
A one-pot selective homodimerisation/hydrogenation strategy for sequential dicarba bridge formation
Authors James Burnley, W. Roy Jackson and Andrea J. Robinson Published Journal of Organic Chemistry Graphical abstract Abstract The installation of interlocked dicarba bridges into peptide sequences requires the development of regioselective and chemoselective methodology. This manuscript describes a one-pot, … Continue reading →
Posted in Dicarba peptides, Metathesis, Publications, Publications 2015
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Tagged dicarba peptides
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A Simple and Practical Preparation of an Efficient Water Soluble Olefin Metathesis Catalyst
Authors Zhen J. Wang and W. Roy Jackson and Andrea J. Robinson Published Green Chemistry Graphical abstract Abstract This study details homogeneous olefin metathesis in water catalysed by a di-ammonium functionalised Ru-alkylidene complex. A facile gram scale synthesis of … Continue reading →
Dicarba Analogues of α-Conotoxin RgIA. Structure, Stability and Activity at Potential Pain Targets
Authors Sandeep Chhabra, Alessia Belgi, Peter Bartels, Bianca van Lierop, Samuel D. Robinson, Shiva N. Kompella, Andrew Hung, Brid P. Callaghan, David J. Adams, Andrea J. Robinson and Raymond S. Norton Published Journal of Medicinal Chemistry Graphical abstract Abstract … Continue reading →
A Concise Cross-Metathesis Route to Enantiopure 1-Azaspirocycles
Authors Zhen James Wang, Nicolas Daniel Spiccia, Christopher James Gartshore, Jayamini Illesinghe, William Roy Jackson and Andrea Jane Robinson Published Synthesis Graphical abstract Abstract The 1-azaspirocyclic ring system can be found in a number of bioactive natural product families. … Continue reading →
Posted in Metathesis, Publications, Publications 2013
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Tagged dicarba peptides, Metathesis
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Combinatorial Approach for the Rapid Determination of Thermochromic Behavior of Binary and Ternary Cholesteric Liquid Crystalline Mixtures
Authors Louise C. van der Werff, Andrea J. Robinson and Ilias L. Kyratzis Published ACS Combinatorial Science Graphical abstract Abstract A combinatorial approach was developed for the rapid determination of thermochromic behavior of a large number of binary and … Continue reading →
Posted in Fibres, Publications, Publications 2012
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Tagged dicarba peptides, Metathesis
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A one pot, metathesis–hydrogenation sequence for the selective formation of carbon–carbon bonds
Authors Andrea J. Robinson, Jomana Elaridi, Jim Patel and W. Roy Jackson Published Chemical Communications Graphical abstract Abstract The selective formation of C–C bonds in complex molecules is one of the major challenges in organic chemistry. Olefin metathesis provides … Continue reading →
Posted in Dicarba peptides, Metathesis, Publications, Publications pre 2009
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Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity
Authors Mohammed Akhter Hossain, K. Johan Rosengren, Suode Zhang, Ross A. D. Bathgate, Geoffrey W. Tregear, Bianca J. van Lierop, Andrea J. Robinson and John D. Wade Published Organic & Biomolecular Chemistry Graphical abstract Abstract Replacement of disulfide bonds … Continue reading →
Controlled Synthesis of (S,S)-2,7-Diaminosuberic Acid: A Method for Regioselective Construction of Dicarba Analogues of Multicystine-Containing Peptides
Authors Jomana Elaridi, Jim Patel, W. Roy Jackson and Andrea J. Robinson Published Journal of Organic Chemistry Graphical abstract Abstract A method to facilitate regioselective formation of multiple dicarba isosteres of cystine is described. A sequence of ruthenium-catalyzed cross … Continue reading →
Electrostatic immobilization of an olefin metathesis pre-catalyst on iron oxide magnetic particles
Authors Matthew J. Byrnes, Andrew M. Hilton, Clint P. Woodward, William R. Jackson and Andrea J. Robinson Published Green Chemistry Graphical abstract Abstract Homogenous Grubbs-type pre-catalysts have played an important role in the application of olefin metathesis to organic … Continue reading →
A simple amine protection strategy for olefin metathesis reactions
Authors Clint Peter Woodward, Nicolas Daniel Spiccia, William Roy Jackson and Andrea Jane Robinson Published Chemical Communications Graphical abstract Abstract Acyclic diamines are valuable feedstocks for polyamide synthesis. Ruthenium-alkylidene catalysed cross metathesis of amino alkenes is problematic and acyl … Continue reading →
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