Category Archives: Publications

A one-pot selective homodimerisation/hydrogenation strategy for sequential dicarba bridge formation

Authors James Burnley, W. Roy Jackson and Andrea J. Robinson Published Journal of Organic Chemistry Graphical abstract   Abstract The installation of interlocked dicarba bridges into peptide sequences requires the development of regioselective and chemoselective methodology. This manuscript describes a one-pot, … Continue reading

Image | Posted on by | Tagged | Leave a comment

A Simple and Practical Preparation of an Efficient Water Soluble Olefin Metathesis Catalyst

Authors Zhen J. Wang and W. Roy Jackson and Andrea J. Robinson Published Green Chemistry Graphical abstract     Abstract This study details homogeneous olefin metathesis in water catalysed by a di-ammonium functionalised Ru-alkylidene complex. A facile gram scale synthesis of … Continue reading

Posted in Metathesis, Publications, Publications 2015 | Tagged | Leave a comment

Dicarba Analogues of α-Conotoxin RgIA. Structure, Stability and Activity at Potential Pain Targets

Authors Sandeep Chhabra, Alessia Belgi, Peter Bartels, Bianca van Lierop, Samuel D. Robinson, Shiva N. Kompella, Andrew Hung, Brid P. Callaghan, David J. Adams, Andrea J. Robinson and Raymond S. Norton Published Journal of Medicinal Chemistry Graphical abstract   Abstract … Continue reading

Posted in Conotoxins, Metathesis, Publications, Publications 2014 | Leave a comment

A Concise Cross-Metathesis Route to Enantiopure 1-Azaspirocycles

Authors Zhen James Wang, Nicolas Daniel Spiccia, Christopher James Gartshore, Jayamini Illesinghe, William Roy Jackson and Andrea Jane Robinson Published Synthesis Graphical abstract   Abstract The 1-azaspirocyclic ring system can be found in a number of bioactive natural product families. … Continue reading

Posted in Metathesis, Publications, Publications 2013 | Tagged , | Leave a comment

Combinatorial Approach for the Rapid Determination of Thermochromic Behavior of Binary and Ternary Cholesteric Liquid Crystalline Mixtures

Authors Louise C. van der Werff, Andrea J. Robinson and Ilias L. Kyratzis Published ACS Combinatorial Science Graphical abstract   Abstract A combinatorial approach was developed for the rapid 
determination of thermochromic behavior of a large number of binary 
and … Continue reading

Posted in Fibres, Publications, Publications 2012 | Tagged , | Leave a comment

A one pot, metathesis–hydrogenation sequence for the selective formation of carbon–carbon bonds

Authors Andrea J. Robinson, Jomana Elaridi, Jim Patel and W. Roy Jackson Published Chemical Communications Graphical abstract   Abstract The selective formation of C–C bonds in complex molecules is one of the major challenges in organic chemistry. Olefin metathesis provides … Continue reading

Posted in Dicarba peptides, Metathesis, Publications, Publications pre 2009 | Tagged , | Leave a comment

Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

Authors Mohammed Akhter Hossain, K. Johan Rosengren, Suode Zhang, Ross A. D. Bathgate, Geoffrey W. Tregear, Bianca J. van Lierop, Andrea J. Robinson and John D. Wade Published Organic & Biomolecular Chemistry Graphical abstract   Abstract Replacement of disulfide bonds … Continue reading

Posted in Dicarba peptides, Metathesis, Publications, Publications 2009 | Leave a comment

Controlled Synthesis of (S,S)-2,7-Diaminosuberic Acid: A Method for Regioselective Construction of Dicarba Analogues of Multicystine-Containing Peptides

Authors Jomana Elaridi, Jim Patel, W. Roy Jackson and Andrea J. Robinson Published Journal of Organic Chemistry Graphical abstract   Abstract A method to facilitate regioselective formation of multiple dicarba isosteres of cystine is described. A sequence of ruthenium-catalyzed cross … Continue reading

Posted in Dicarba peptides, Metathesis, Publications, Publications pre 2009 | Leave a comment

Electrostatic immobilization of an olefin metathesis pre-catalyst on iron oxide magnetic particles

Authors Matthew J. Byrnes, Andrew M. Hilton, Clint P. Woodward, William R. Jackson and Andrea J. Robinson Published Green Chemistry Graphical abstract   Abstract Homogenous Grubbs-type pre-catalysts have played an important role in the application of olefin metathesis to organic … Continue reading

Posted in Metathesis, Publications, Publications 2012 | Leave a comment

A simple amine protection strategy for olefin metathesis reactions

Authors Clint Peter Woodward, Nicolas Daniel Spiccia, William Roy Jackson and Andrea Jane Robinson Published  Chemical Communications Graphical abstract   Abstract Acyclic diamines are valuable feedstocks for polyamide synthesis. Ruthenium-alkylidene catalysed cross metathesis of amino alkenes is problematic and acyl … Continue reading

Posted in Metathesis, Publications, Publications 2011 | Leave a comment