Category Archives: Dicarba peptides

Stereoselective Synthesis and Structural Elucidation of Dicarba Peptides

Posted on February 6, 2016 by

Authors Ellen C. Gleeson, Zhen J. Wang, Samuel D. Robinson, Sandeep Chhabra, Christopher A. MacRaild, W. Roy Jackson, Raymond S. Norton and Andrea J. Robinson Published Chemical Communications Graphical abstract   Abstract Preformed, orthogonally-protected Z– and E-diaminosuberic acid residues can be used to synthesise target dicarba peptides. … Continue reading →

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A one-pot selective homodimerisation/hydrogenation strategy for sequential dicarba bridge formation

Posted on August 15, 2015 by

Authors James Burnley, W. Roy Jackson and Andrea J. Robinson Published Journal of Organic Chemistry Graphical abstract   Abstract The installation of interlocked dicarba bridges into peptide sequences requires the development of regioselective and chemoselective methodology. This manuscript describes a one-pot, … Continue reading →

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A one pot, metathesis–hydrogenation sequence for the selective formation of carbon–carbon bonds

Posted on September 20, 2014 by

Authors Andrea J. Robinson, Jomana Elaridi, Jim Patel and W. Roy Jackson Published Chemical Communications Graphical abstract   Abstract The selective formation of C–C bonds in complex molecules is one of the major challenges in organic chemistry. Olefin metathesis provides … Continue reading →

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Solid phase synthesis and structural analysis of novel A-chain dicarba analogs of human relaxin-3 (INSL7) that exhibit full biological activity

Posted on September 20, 2014 by

Authors Mohammed Akhter Hossain, K. Johan Rosengren, Suode Zhang, Ross A. D. Bathgate, Geoffrey W. Tregear, Bianca J. van Lierop, Andrea J. Robinson and John D. Wade Published Organic & Biomolecular Chemistry Graphical abstract   Abstract Replacement of disulfide bonds … Continue reading →

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Controlled Synthesis of (S,S)-2,7-Diaminosuberic Acid: A Method for Regioselective Construction of Dicarba Analogues of Multicystine-Containing Peptides

Posted on September 20, 2014 by

Authors Jomana Elaridi, Jim Patel, W. Roy Jackson and Andrea J. Robinson Published Journal of Organic Chemistry Graphical abstract   Abstract A method to facilitate regioselective formation of multiple dicarba isosteres of cystine is described. A sequence of ruthenium-catalyzed cross … Continue reading →

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Dicarba α‐Conotoxin Vc1.1 Analogues with Differential Selectivity for Nicotinic Acetylcholine and GABAB Receptors

Posted on September 20, 2014 by

Authors Bianca J. van Lierop, Samuel D. Robinson, Shiva N. Kompella, Alessia Belgi, 
Jeffrey R. McArthur, Andrew Hung, Christopher A. MacRaild, David J. Adams, Raymond S. Norton and Andrea J. Robinson Published  ACS Chemical Biology Graphical abstract   Abstract Conotoxins … Continue reading →

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