Authors | Zhen J. Wang, W. Roy Jackson and Andrea J. Robinson |
Published | Organic Letters |
Graphical abstract | |
Abstract |
We have recently described synthetic routes to the azaspirocyclic ring systems found in marine tricyclic alkaloids such as Cylindricine A utilising a Ru-alkylidene cross-metathesis reaction and acid-catalysed cyclisation. Construction of the third ring, however, requires cross coupling of a highly hindered, α-substituted methylenecycloalkane. CM of such olefins is highly challenging. This paper describes a generic steric-reversal strategy that can be used to react previously unreactive, sterically demanding alkenes using commercially available catalyst. |
Citation | J. Wang, W. R. Jackson, A. J. Robinson, Organic Letters, 2013, 15(12), 3006-3009. |
Article | |
Doi | DOI: 10.1021/ol401194h |
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