A simple amine protection strategy for olefin metathesis reactions

Authors Clint Peter Woodward, Nicolas Daniel Spiccia, William Roy Jackson and Andrea Jane Robinson
Published  Chemical Communications
Graphical abstract  



Acyclic diamines are valuable feedstocks for polyamide synthesis. Ruthenium-alkylidene catalysed cross metathesis of amino alkenes is problematic and acyl derivatisation can result in less efficient syntheses, poor catalyst turnover and isomerisation. Temporary amine masking via stable and soluble ammonium salts delivers cyclic and acyclic aminoalkenes in high yield and purity.


C. P. Woodward, N. D. Spiccia, W. R. Jackson, A. J. Robinson, Chem. Commun., 2011, 47, 779–781.


Doi DOI: 10.1039/c0cc03716h
This entry was posted in Metathesis, Publications, Publications 2011. Bookmark the permalink.

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