A one-pot selective homodimerisation/hydrogenation strategy for sequential dicarba bridge formation

Authors James Burnley, W. Roy Jackson and Andrea J. Robinson
Published Journal of Organic Chemistry
Graphical abstract  peptides2
Abstract

The installation of interlocked dicarba bridges into peptide sequences requires the development of regioselective and chemoselective methodology. This manuscript describes a one-pot, chemoselective synthesis of three 2,7-diaminosuberic acid derivatives from an alkyne, a cobalt-carbonyl protected alkyne and an alkene using metathesis and homogeneous hydrogenation catalysis.

Citation James Burnley, W. Roy Jackson and Andrea J. Robinson, J. Org. Chem., 2015, 80(18), 9057-9063
Pdf Article
Doi 10.1021/acs.joc.5b01312
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Image | This entry was posted in Dicarba peptides, Metathesis, Publications, Publications 2015 and tagged . Bookmark the permalink.

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